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Evidence-based longevity interventions, aging research, and compounds for lifespan and healthspan optimization.
A direct NAD+ precursor that restores declining cellular energy metabolism and activates sirtuins for anti-aging effects.
A polyphenol found in red wine and grapes that activates sirtuins and AMPK, studied extensively for its anti-aging and cardioprotective properties.
A naturally occurring polyamine that induces autophagy and has been associated with reduced all-cause mortality in epidemiological studies.
A ubiquitous flavonoid with senolytic, anti-inflammatory, and antiviral properties — a key component of the dasatinib + quercetin senolytic protocol.
A plant alkaloid that activates AMPK as effectively as metformin, improving blood sugar control, lipid profiles, and potentially activating longevity pathways.
An essential mitochondrial coenzyme that declines with age, critical for cellular energy production and serving as the body's most important lipid-soluble antioxidant.
A powerful glutathione precursor and mucolytic agent with broad applications in liver protection, mental health, respiratory health, and longevity support.
A conditionally essential amino acid that declines dramatically with age — a 2023 Science paper showed taurine supplementation extended lifespan by 10-12% in mice and improved healthspan across multiple species.
The most well-supported supplement in existence with evidence across cardiovascular health, brain function, inflammation, and all-cause mortality — the one supplement everyone should take.
The essential fat-soluble vitamin duo — D3 for immune function, bone health, and gene expression; K2 to direct calcium to bones and prevent arterial calcification.
The simplest amino acid with outsized importance — a collagen precursor, glutathione cofactor, sleep enhancer, and methyl group buffer that becomes conditionally essential with age.
A Krebs cycle intermediate that extended lifespan by 12% in mice (Buck Institute) and compressed morbidity — meaning animals lived healthier for longer, not just longer.
A postbiotic metabolite that activates mitophagy — the selective recycling of damaged mitochondria — shown to improve muscle endurance and mitochondrial health in human clinical trials.
The most powerful carotenoid antioxidant — 6000x stronger than vitamin C at quenching singlet oxygen. Protects mitochondria, skin, eyes, and cardiovascular system from oxidative damage.
The most potent natural Nrf2 activator — unlocking the body's entire antioxidant defense system while providing detoxification support and epigenetic modulation for longevity.
A glycosaminoglycan that holds 1000x its weight in water — declining sharply with age, contributing to joint degeneration, skin aging, and reduced tissue hydration throughout the body.
Bioactive peptide fragments from hydrolyzed collagen that stimulate the body's own collagen production — with clinical evidence for skin elasticity, joint health, bone density, and gut lining repair.