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Also known as: 2-Aminoethanesulfonic Acid
A conditionally essential amino acid that declines dramatically with age — a 2023 Science paper showed taurine supplementation extended lifespan by 10-12% in mice and improved healthspan across multiple species.
Taurine is the most abundant free amino acid in the body, concentrated in the heart, brain, retina, and skeletal muscle. A landmark 2023 paper in Science by Vijay Yadav's team demonstrated that taurine deficiency is a driver of aging across species — and supplementation extended both lifespan and healthspan.
Yadav et al. (2023) showed:
The mouse lifespan study used ~1000mg/kg/day, which translates to roughly 3-6g/day in humans by allometric scaling. Human cardiovascular trials have safely used 1-6g/day.
Taurine stabilizes cell membranes, modulates calcium signaling, acts as an osmolyte for cell volume regulation, conjugates bile acids for lipid metabolism, and functions as an intracellular antioxidant. It modulates GABA-A and glycine receptors and stabilizes mitochondrial electron transport chain function.
Typical Dose
1000-6000mg
Frequency
Daily (1-2 doses)
Cycle Length
Ongoing
Half-Life
~1-2 hours
Landmark Science paper 2023. Multiple human cardiovascular RCTs. GRAS status. Decades of safe use in energy drinks and supplements.
Extremely safe. Present in energy drinks worldwide with no adverse effects. Clinical trials up to 6g/day well-tolerated. Rare: GI discomfort at very high doses. May potentiate effects of blood pressure medications.
An mTOR inhibitor and FDA-approved immunosuppressant being investigated as the most promising pharmacological intervention for extending lifespan.
A direct NAD+ precursor that restores declining cellular energy metabolism and activates sirtuins for anti-aging effects.
The world's most prescribed diabetes drug, now being studied as a potential anti-aging intervention in the landmark TAME clinical trial.