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Also known as: Polyamine
A naturally occurring polyamine that induces autophagy and has been associated with reduced all-cause mortality in epidemiological studies.
Spermidine is a polyamine found in all living cells, with high concentrations in wheat germ, soybeans, aged cheese, and mushrooms. It is one of the most promising longevity compounds due to its ability to induce autophagy — the cellular recycling process.
A 20-year prospective study of 829 participants found that those in the highest tertile of spermidine intake had significantly lower all-cause mortality compared to the lowest tertile — equivalent to ~5 years of additional life.
Spermidine induces autophagy through inhibition of acetyltransferase EP300 and activation of the MAP1S-mediated autophagy pathway. It also stabilizes mitochondrial function, reduces inflammation through NF-κB modulation, and supports telomere maintenance.
Typical Dose
1-6mg
Frequency
Daily
Cycle Length
Ongoing
Half-Life
~2-3 hours
Strong epidemiological data. Phase II clinical trials for cognitive decline (SmartAge trial). Generally recognized as safe dietary compound.
Excellent safety — naturally present in food and all human cells. No significant adverse effects at supplemental doses. Levels decline with age, supporting supplementation rationale.
An mTOR inhibitor and FDA-approved immunosuppressant being investigated as the most promising pharmacological intervention for extending lifespan.
A direct NAD+ precursor that restores declining cellular energy metabolism and activates sirtuins for anti-aging effects.
The world's most prescribed diabetes drug, now being studied as a potential anti-aging intervention in the landmark TAME clinical trial.