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Also known as: trans-Resveratrol, 3,5,4'-Trihydroxystilbene
A polyphenol found in red wine and grapes that activates sirtuins and AMPK, studied extensively for its anti-aging and cardioprotective properties.
Resveratrol is a stilbenoid polyphenol produced by plants in response to stress. Found in red wine, grapes, and berries, it gained fame after David Sinclair's 2003 Nature paper showed it activated SIRT1 and extended lifespan in yeast.
Resveratrol has notoriously poor oral bioavailability (~1%). Micronized and liposomal formulations significantly improve absorption. Taking with a fat source also helps.
Resveratrol activates SIRT1 (and to a lesser extent SIRT3/5), which deacetylates PGC-1α to enhance mitochondrial biogenesis. It activates AMPK independently, inhibits NF-κB inflammatory signaling, and provides antioxidant effects through direct free radical scavenging.
Typical Dose
250-1000mg
Frequency
Daily (with fat source)
Cycle Length
Ongoing
Half-Life
~1-3 hours
Extensive preclinical data. Multiple human clinical trials with mixed results (often attributed to bioavailability issues). Sinclair lab continues active research.
Generally safe at recommended doses. GI discomfort at high doses (>2g). May interact with blood thinners (antiplatelet effect). Estrogenic activity — caution in hormone-sensitive conditions.
An mTOR inhibitor and FDA-approved immunosuppressant being investigated as the most promising pharmacological intervention for extending lifespan.
A direct NAD+ precursor that restores declining cellular energy metabolism and activates sirtuins for anti-aging effects.
The world's most prescribed diabetes drug, now being studied as a potential anti-aging intervention in the landmark TAME clinical trial.