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Also known as: Hydrolyzed Collagen, Collagen Hydrolysate, Type I/III Collagen
Bioactive peptide fragments from hydrolyzed collagen that stimulate the body's own collagen production — with clinical evidence for skin elasticity, joint health, bone density, and gut lining repair.
Collagen is the most abundant protein in the human body (30% of total protein), forming the structural framework of skin, bones, tendons, ligaments, and gut lining. Production declines ~1.5% per year after age 25. Hydrolyzed collagen peptides (2-5 kDa fragments) are bioactive — they don't just provide amino acids, they signal fibroblasts to produce MORE collagen.
Vitamin C is an essential cofactor for prolyl hydroxylase — the enzyme that stabilizes the collagen triple helix structure. Taking 50mg vitamin C with collagen peptides 30-60 minutes BEFORE exercise maximizes collagen synthesis in tendons and ligaments (Shaw et al., 2017).
| Type | Primary Location | Supplement Source | |---|---|---| | I | Skin, bones, tendons | Bovine, marine | | II | Cartilage | Chicken sternum | | III | Skin, blood vessels | Bovine | | V | Cell surfaces, hair | Bovine |
For general anti-aging: Type I/III (bovine or marine) For joint cartilage specifically: Type II (undenatured — UC-II)
Hydrolyzed collagen peptides (particularly Pro-Hyp and Hyp-Gly dipeptides) are absorbed intact from the gut and accumulate in skin and cartilage. They stimulate fibroblast collagen synthesis through mechanotransduction signaling, upregulate hyaluronic acid production, and provide the specific amino acid profile (glycine, proline, hydroxyproline) required for endogenous collagen assembly.
Typical Dose
10-20g
Frequency
Daily (with vitamin C, before exercise)
Cycle Length
Ongoing
Half-Life
~4-6 hours (peptides), weeks (tissue effects)
Multiple RCTs for skin, joints, and bones. Cochrane interest for OA. Shaw et al. exercise protocol published in American Journal of Clinical Nutrition.
Extremely safe. No adverse effects in any clinical trial. Derived from food sources (bovine, marine, chicken). Allergen consideration: marine collagen for those with fish allergies (rare cross-reactivity). Bovine for those avoiding fish.
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