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Also known as: ACTH(4-10) analog, Heptapeptide
A synthetic heptapeptide nootropic derived from ACTH that enhances BDNF expression, memory, and cognitive function with neuroprotective properties.
Semax is a synthetic analog of the adrenocorticotropic hormone (ACTH) fragment 4-10, developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It has been approved in Russia since 2011 for conditions including stroke recovery, cognitive disorders, and optic nerve disease.
Unlike many nootropics, Semax has a strong pharmacological profile with government-approved medical use, decades of clinical research, and a clear mechanism of action through BDNF modulation.
Semax increases BDNF and NGF expression in the hippocampus and cortex. It modulates serotonergic and dopaminergic systems, enhances acetylcholine release, and provides neuroprotection through antioxidant pathways. It does not affect cortisol levels despite its ACTH origin.
Typical Dose
300-900mcg
Frequency
Daily (intranasal)
Cycle Length
2-4 weeks on, 1-2 weeks off
Half-Life
~30 minutes (but effects last hours)
Approved pharmaceutical in Russia since 2011. Extensive Russian clinical research. Limited Western clinical trials.
Excellent safety profile. No significant adverse effects in clinical use. No hormonal disruption despite ACTH derivation. Non-addictive with no withdrawal symptoms.
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