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Also known as: Hericium erinaceus, Yamabushitake, Hou Tou Gu
A medicinal mushroom with potent NGF-stimulating properties that supports cognitive function, nerve regeneration, and mental clarity.
Lion's Mane (Hericium erinaceus) is an edible medicinal mushroom with a long history in traditional Chinese medicine. Modern research has validated its remarkable neurotrophic properties, particularly its ability to stimulate nerve growth factor (NGF) synthesis.
Lion's Mane contains two unique classes of compounds: hericenones (found in the fruiting body) and erinacines (found in the mycelium). Both cross the blood-brain barrier and stimulate NGF, but through different mechanisms.
Hericenones and erinacines stimulate NGF synthesis in the brain by activating the PKC and JNK pathways. NGF promotes neuronal growth, maintenance, myelination, and survival. Lion's Mane also reduces amyloid-beta plaque formation and modulates inflammatory cytokines.
Typical Dose
500-3000mg
Frequency
Daily
Cycle Length
Ongoing (safe for continuous use)
Half-Life
N/A (natural compound)
Multiple human clinical trials. Strong preclinical evidence. Long history of safe traditional use.
Exceptionally safe. Generally recognized as safe (GRAS). Rare reports of itchy skin (likely due to increased NGF). Avoid if allergic to mushrooms.
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