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Also known as: GVS-111, N-Phenylacetyl-L-prolylglycine ethyl ester, Omberacetam
A potent dipeptide nootropic 1000x more concentrated than piracetam, enhancing memory consolidation, learning, and providing neuroprotective effects.
Noopept is a synthetic dipeptide nootropic developed in Russia in the 1990s. Structurally related to the racetam family but 1000x more potent by weight, it is one of the most widely used cognitive enhancers globally.
Unlike piracetam which primarily modulates AMPA receptors, Noopept acts on both AMPA and NMDA receptors while also increasing BDNF and NGF — providing a broader cognitive enhancement profile.
Noopept modulates AMPA and NMDA glutamate receptors, increasing synaptic plasticity. It upregulates BDNF and NGF expression in the hippocampus, provides neuroprotection through antioxidant and anti-inflammatory mechanisms, and enhances acetylcholine transmission.
Typical Dose
10-30mg
Frequency
Daily (2-3 doses)
Cycle Length
1-3 months on, 1 month off
Half-Life
~30-60 minutes
Approved in Russia. Extensive clinical and preclinical research. Available as OTC supplement in many countries.
Very well-tolerated. Rare: headache (often from choline depletion — stack with choline source), irritability at high doses. No significant adverse effects in clinical studies.
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