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Also known as: MgT, Magtein, Magnesium Threonate
The only form of magnesium clinically shown to cross the blood-brain barrier and increase brain magnesium levels — improving learning, memory, and sleep quality.
Magnesium L-Threonate (MgT) was developed at MIT by Guosong Liu's lab specifically to increase brain magnesium. While many magnesium forms exist (glycinate, citrate, oxide), MgT is the only one with published evidence of raising cerebrospinal fluid magnesium levels.
Magnesium is a cofactor for 600+ enzymatic reactions and is critical for NMDA receptor function, synaptic plasticity, and neuronal energy metabolism. Brain magnesium declines with age, and most dietary magnesium doesn't effectively cross the BBB.
Liu et al. (2010) showed that elevating brain magnesium by just 15% dramatically improved both short-term and long-term memory in rats, with effects equivalent to rejuvenating the brain by several years.
MgT is considered a foundational nootropic — it optimizes the substrate that other nootropics work on. Take it as part of your Tier 1 foundation before adding more exotic compounds.
MgT crosses the BBB via the L-threonate moiety, which is actively transported. Elevated brain Mg²⁺ increases NMDA receptor signaling at active synapses while reducing background noise, enhancing signal-to-noise ratio. It increases synaptic density, promotes neuroplasticity through NR2B subunit upregulation, and reduces inflammatory cytokines.
Typical Dose
1000-2000mg
Frequency
Daily (evening preferred)
Cycle Length
Ongoing (no cycling needed)
Half-Life
~2 hours (but brain levels accumulate)
Published in Neuron (2010). Phase II clinical trial for cognitive aging (LMTM study). Magtein branded ingredient with clinical backing.
Very safe. Most common: GI discomfort (less than other Mg forms). Drowsiness at higher doses (beneficial if taken evening). No significant interactions. Safe for long-term daily use.
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