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Also known as: L-Alpha Glycerylphosphorylcholine, Choline Alfoscerate
The most bioavailable choline source that crosses the blood-brain barrier, supporting acetylcholine synthesis, memory, and physical performance.
Alpha-GPC is a naturally occurring choline compound found in the brain. It is the most efficient choline source for raising brain acetylcholine levels, making it a foundational component of most nootropic stacks.
Alpha-GPC is the recommended choline source to stack with racetams and other cholinergic nootropics. It prevents the headaches that can occur when acetylcholine precursors are depleted by enhanced cholinergic activity.
Alpha-GPC is cleaved to choline and glycerophosphate in the gut. Choline crosses the BBB and is converted to acetylcholine via choline acetyltransferase. Glycerophosphate supports neuronal membrane phospholipid synthesis. Also stimulates GH release via cholinergic pathways.
Typical Dose
300-600mg
Frequency
Daily (1-2 doses)
Cycle Length
Ongoing
Half-Life
~4-6 hours
Multiple human clinical trials. Approved as a prescription drug in Europe for cognitive decline. Available as supplement in the US.
Excellent safety profile. Rare: GI discomfort, headache, dizziness. Very well-tolerated at recommended doses. Long history of safe clinical use.
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