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Rapid Antidepressant Effects: Produces behavioral improvements within 4 days in rodent models; reduces immobility in forced swim tests and decreases latency to feed in novel environments.
PE-22-28 functions as a potent and selective antagonist of TREK-1 (KCNK2) two-pore domain potassium channels. By blocking TREK-1, it depolarizes neurons and enhances excitability, leading to increased firing of serotonergic neurons and elevated monoamine neurotransmission.
Typical Dose
50-200mcg
A 15-amino-acid peptide derived from human gastric juice with potent tissue-healing and anti-inflammatory properties.
Fertility Preservation: Maintains testosterone and spermatogenesis during TRT.
Potential Benefits: Increases in lean body mass, reductions in adipose tissue, improved metabolic parameters.