The OPTMZ Supplement Tier List: What Actually Works

A rigorous evidence-based ranking of 50+ supplements across 5 tiers — from essential foundations to speculative compounds. Includes dosing, timing, and what to skip.

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Every supplement ranked by strength of evidence, practical benefit, and cost-effectiveness. Tier S (essential for everyone) through Tier F (skip it). No sponsored rankings, no affiliate bias.

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supplementstier listrankingevidence-basedguide